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. 2018 Feb 26;2(4):421–436. doi: 10.1002/hep4.1163

Figure 5.

Figure 5

CXCL‐10 distribution in treatment‐naive AIH livers colocalizes with CD56+ NK cells and FOXP3+ Tregs. (A) CXCR3 expression by total Tregs at baseline and after 4 months therapy. Wilcoxon test, *P < 0.05. (B,C) Dual staining of CXCL‐10 and either (B) CD56 or (C) FOXP3 on liver biopsy sections taken at diagnosis of AIH (CXCL‐10, brown staining; FOXP3+Tregs, CD56+NK cells, red staining). (D) CXCL‐10 concentrations in culture supernatants prepared from untreated and IFNγ + TNFα‐treated hepatocytes and biliary epithelial cells. Data are mean ± SEM. Abbreviation: BEC, biliary epithelial cell.