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. 2018 Feb 26;2(4):421–436. doi: 10.1002/hep4.1163

Figure 6.

Figure 6

Regulation of NK cell function by activated regulatory and nonregulatory T cells. (A,B) NK cells, Tregs, and non‐Tregs were isolated from peripheral blood. NK cell degranulation (CD107a), IFNγ, and TNFα production, with overnight IL‐12 (20 ng/mL) + IL‐15 (20 ng/mL) stimulation monitored by flow cytometry in the presence or absence of activated Tregs or non‐Tregs. (A) Representative and summary data on NK degranulation and cytokine production with stimulation. (B) IFNγ production by NK cells cultured overnight alone or 1:1 with either Tregs or non‐Tregs under IL‐12 (20 ng/mL) + IL‐15 (20 ng/mL) stimulation. (C‐E) Expression of immune cell surface markers in responders and nonresponders after 4 months corticosteroid treatment. CXCR3 MFI on (C) NKbright cells and (D) CD4 T cells. (E) PD1 MFI on CD4 T cells. Abbreviation: MFI, median fluorescence intensity.