Figure 6.
Controlled cortical impact (CCI) increases inhibitory synaptic decay. (A) Voltage‐clamp recordings of spontaneous inhibitory postsynaptic current (sIPSC) in control or CCI‐injured animals. For inhibitory recordings, glutamate receptor antagonists (APV/DNQX or kynurenate) were applied. (B) Overlayed and amplitude‐scaled average sIPSC recorded from control (black) and CCI (red) animals. (C) and (D) Average sIPSC properties for control (n = 9) or CCI (n = 16). No statistical difference was found for sIPSC interevent interval (P = 0.55), amplitude (P = 0.95) or charge transfer (P = 0.15). Vhold = −70 mV. *P < 0.05.