Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Apr;4(2):a002246. doi: 10.1101/mcs.a002246

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Nordfors et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial License, which permits reuse and redistribution, except for commercial purposes, provided that the original author and source are credited.

PMC Copyright notice

Figure 2. — Both the mother and the child carried a germline mutation in both TP53 and ATRX genes. (A) The sequencing coverage and TP53 allele fraction information in blood and tumor samples as visualized in integrative genomics viewer (IGV). The green color represents the variant allele. Copy-neutral LOH was observed in all the tumor samples. The sequencing coverage range is indicated in square brackets. The exon, transcript base, and amino acid information in the major transcript (NM_000546) are marked above the figure. (Bottom) TP53 mutation is located at the DNA-binding domain. (B) The sequencing coverage and ATRX allele fraction information in blood and tumor samples as visualized in IGV. The orange color represents the variant allele. Copy-neutral LOH was observed in both AT/RT tumor samples. The exon, transcript base, and amino acid information in the major transcript (NM_000489) are marked above the figure. (Bottom) ATRX mutation is located at the SNF2N domain.