Table 1.
Clinical characteristics and outcomes of patients
| Patient ID | Type | Site of sample analyzed | Age at diagnosis | Sample analyzed: primary/recurrent (date) | Preceding therapya | Date of initial diagnosis | Primary: WD/DDb (treatment) | Recurrences (treatment, path if availableb) | Site(s) of recurrence | D/AW/AWO (Date of death or last F/U) |
|---|---|---|---|---|---|---|---|---|---|---|
| DWN-1 | DD | Abdomen | 59 | Recurrent (3/20/07) | No | 10/28/02 | DD (S) | 2004 (R → S, WD), 2005 (C → S, WD), 2007 (S, DD), 2007 (S, DD), 2009 (C → S, DD) | Retroperitoneum and peritoneal cavity | D (8/7/2009) |
| WD | Retroperitoneum | Recurrent (6/2/09) | Yes (C) | |||||||
| N | Fat | |||||||||
| DWN-2 | DD | Retroperitoneum | 53 | Recurrent (6/3/08) | No | 7/28/05 | Cellular WD (R → S) | 2006 (S, DD), 2007 (S, DD), 2008 (S, DD), 2008 (attempted S, DD) | Retroperitoneum and peritoneal cavity | D (3/16/2009) |
| WD | Retroperitoneum | Recurrent (6/3/08) | No | |||||||
| N | Fat | |||||||||
| DWN-3 | DD | Retroperitoneum | 52 | Primary (12/9/2014) | No | 11/18/14 | DD with cartilaginous metaplasia (S) | 2016 (C, DD) | Cervical spine, right iliac bone, right psoas | AW (6/29/2017) Receiving C |
| WD | Retroperitoneum | Primary (12/9/2014) | No | |||||||
| N | Kidney | |||||||||
| DWN-4 | DD | Retroperitoneum | 52 | Primary (4/28/2015) | Yes (C) | 12/23/14 | DD (C → S) | None | NA | AWO (3/10/2017) |
| WD | Retroperitoneum | Primary (4/28/2015) | Yes (C) | |||||||
| N | Kidney | |||||||||
| OWN-5 | DD | Retroperitoneum | 68 | Primary (5/5/2015) | No | 2/24/15 | DD (S) | None | NA | AWO (5/25/2017) |
| WD | Retroperitoneum | Primary (5/5/2015) | No | |||||||
| N | Kidney | |||||||||
| DWN-6 | DD | Left thigh | 61 | Recurrent (7/6/2015) | Yes (R) | 12/22/10 | Cellular WD (S) | 2015 (R → S, DD) | Left thigh | AWO (4/19/2017) |
| WD | Left thigh | Recurrent (7/6/2015) | Yes (R) | |||||||
| N | Skeletal muscle | |||||||||
| DWN-7 | DD | Retroperitoneum | 79 | Primary (7/20/2015) | No | 5/22/15 | DD (S) | None | NA | AWO (6/22/2017) |
| WD | Retroperitoneum | Primary (7/20/2015) | No | |||||||
| N | Kidney | |||||||||
| DWN-8 | DD | Retroperitoneum | 57 | Primary (9/3/2015) | Yes (C → R) | 11/10/14 | DD (C → R → S → C) | None | NA | AWO (6/30/2017) |
| WD | Retroperitoneum | Primary (9/3/2015) | Yes (C → R) | |||||||
| N | Skeletal muscle | |||||||||
| DWN-10 | DD | Pelvis/retroperitoneum | 41 | Recurrent (12/10/2015) | Yes (C) | 8/2/12 | DD (S) | 2013 (C → S, WD), 2014 (S, DD), 2015 (C → S, DD), 2016 (C → R) | Pelvis, retroperitoneum | AW (6/20/2017) Awaiting S |
| WD | Pelvis | Recurrent (12/10/2015) | Yes (C) | |||||||
| N | Smooth muscle | |||||||||
| FF-1 | DD | Retroperitoneum | 34 | Primary (12/18/1997) | No | 12/18/97 | DD (S) | 1998 (C) | Retroperitoneum | D (12/4/1998) |
| WD | Retroperitoneum | Primary (12/18/1997) | No | |||||||
| N | Appendix | |||||||||
| FF-3 | WD | Retroperitoneum | 25 | Recurrent (6/17/2005) | No | 8/20/89 | Cellular WD (S) | 1993 (S, ?), 1997 (S, ?), 1999 (S, DD), 1999 (C → S, ?), 2002 (C), 2005 (S, DD) | Retroperitoneum | D (1/17/2010) |
| DD | Retroperitoneum | Recurrent (6/17/2005) | No | |||||||
| N | Small bowel | |||||||||
| FF-4 | DD | Peritoneum | 65 | Recurrent (1/23/2006) | No | 2000 | ? (S) | 2004 (S, ?), 2005 (C) | Retroperitoneum | D (2/3/2008) |
| WD | Kidney | Recurrent (1/23/2006) | No | |||||||
| N | Kidney | |||||||||
| FF-5 | WD | Retroperitoneum | 67 | Primary (11/19/1997) | Yes (C/R) | 8/19/97 | DD (C/R → S) | 1999 (C) | Retroperitoneum, lung | D (10/12/2001) |
| DD | Retroperitoneum | Primary (11/19/1997) | Yes (C/R) | |||||||
| N | Colon | |||||||||
| FF-7 | WD | Diaphragm | 77 | Residual primary (4/5/2005) | No | 1/17/05 | DD (S) | 2006 (S, DD) | Retroperitoneum and peritoneal cavity | D (4/6/2006) |
| DD | Left upper quadrant | Residual primary (4/5/2005) | No | |||||||
| N | Fat | |||||||||
| FF-8 | WD | Retroperitoneum | 75 | Recurrent (10/30/1998) | No | 9/30/97 | DD (S) | 1998 (C → S, DD), 1998 (S, DD) | Retroperitoneum and peritoneal cavity | D (6/8/1999) |
| DD | Retroperitoneum | Recurrent (10/30/1998) | No | |||||||
| N | Skeletal muscle and fat | |||||||||
| FF-9 | DD | Retroperitoneum | 56 | Primary (5/1/2003) | No | 3/21/03 | DD (S) | 2004 (C → S, DD), 2005 (R → S, DD), 2005 (C, DD) | Retroperitoneum and peritoneal cavity | D (3/8/2006) |
| WD | Retroperitoneum | Primary (5/1/2003) | No | |||||||
| N | Kidney | |||||||||
| FF-10 | WD | Retroperitoneum | 43 | Recurrent (1/21/2005) | No | 4/11/94 | ? Scrotal mass (S) | 2002 (C/R → S, DD), 2005 (S, DD), 2005 | Retroperitoneum and peritoneal cavity | D (10/28/2007) |
| DD | Retroperitoneum | Recurrent (1/21/2005) | No | |||||||
| N | Spleen |
S, surgery; R, radiation; C, chemotherapy; C/R, chemoradiation; ?, data unavailable; D, died with disease; AW, alive with disease; AWO, alive without recurrence.
aAny therapy within 3 months prior to surgery.
bDD: Any presence of DD liposarcoma in the specimen.