Table 6.

Classes of P. mirabilis fimbriae and their contribution to virulence

Fimbria	Genes	Classa	Implicated in virulenceb,c								Protein	MrpJ paralog	Ref
			IC	CO	STM	SS CAUTI	CO CAUTI	Exp	In vitro
MR/P′	PMI0254-PMI0261	π				✓	✓				PMI0261	124
MR/P	PMI0262-PMI0271	π	✓	✓			✓	↑	✓	✓*	PMI0271	43, 95, 101, 124, 126, 141, 207, 214, 222, 223, 226, 227, 229–232, 242, 355
Fimbria 3	PMI0296-PMI0304	π					✓				PMI0296	124
UCA	PMI0532-PMI0536	γ1	✓	✓		✓	✓	↓	✓	✓	PMI0532	101, 124, 126, 225, 233–238
Fimbria 5	PMI1060-PMI1067	π					✓	↓			PMI1060	124, 126
Fimbria 6	PMI1185-PMI1190	γ1									None
Fimbria 7	PMI1193-PMI1197	γ1									None
Fimbria 8	PMI1464-PMI1470	γ1						↓		✓	PMI1470	101, 126
PMF	PMI1877-PMI1881	π	✓	✓		✓	✓	↓		✓*	None	101, 124, 126, 213, 214, 241, 242, 248
Fimbria 10	PMI2207-PMI2214	γ1					✓				PMI2209, PMI2207	124
PMP	PMI2216-PMI2224	π				✓	✓			✓	PMI2224	124, 245
Fimbria 12	PMI2533-PMI2539	γ2					✓				None	124
ATF	PMI2728-PMI2733	γ1	⦸	⦸			✓			✓	PMI2733	101, 124, 244
Fimbria 14	PMI2997-PMI3003	ND			✓		✓	↑		✓	PMI3003	101, 124, 126, 154
Fimbria 15	PMI3086-PMI3093	π					✓	✓			None	124, 126
Fimbria 16	PMI3348-PMI3352	γ1					✓				None	124
Fimbria 17	PMI3435-PMI3440	γ1					✓				None	124

Table adapted from reference 19.

^a Greek classification was determined as in references 206 and 100. The operon encoding Fimbria 14 lacks a chaperone, and thus cannot be classified in the Greek system.

^b The mutant was tested in: IC, independent challenge experiment; CO, cochallenge experiment; STM, signature-tagged mutagenesis experiment; SS CAUTI, Tn-Seq CAUTI model with P. mirabilis alone; CO CAUTI, Tn-Seq CAUTI model during coinfection with Providencia stuartii; Exp, expressed in vivo; in vitro, virulence attributes (e.g., cell adherence, hemagglutination) detected using in vitro assays.

^c ✓, positive for the trait; ⦸, negative for the trait; ↑, induced in vivo compared with in vitro culture; ↓, repressed in vivo compared with in vitro culture.

^* Immunogenic.