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. 2018 Apr 2;13(4):e0193236. doi: 10.1371/journal.pone.0193236

Fig 4. Effect of treatment on histological changes in the kidney measured at termination.

Fig 4

Combined histology score for glomerular lesions (includes mesangial expansion, endocapillary proliferation, glomerular deposits and extracapillary proliferation) for (A) RPC1063 and (B) RP 101075. Combined histology score for tubular and interstitial lesions (includes interstitial infiltrates, tubular atrophy and interstitial fibrosis) for (C) RPC1063 and (D) RP-101075. (E) Inflammatory infiltrates in a representative (E) vehicle-treated animal and (F) RPC1063 3 mg/kg-treated animal. Calibration bars (E,F) 1 mm, 4× objective, 11×s1p magnification. Histology data presented as mean ± SEM. Baseline data collected from NZBWF1 mice sacrificed at week 23 prior to dosing initiation. *p <0.05, **p <0.01, ***p <0.001, ****p <0.0001, ns = not significant, for treatment versus vehicle-treated animals.