Table 1.

Characteristics and research trends of biosensors

Technology	Advantages	Disadvantages	Development trends	Remarks
SPR Biosensor	Real-time analysis possible	Better sensitivity required	Currently prevailing	Gold nanoparticles and AFM* applied research in progress
QCM Biosensor	Real-time analysis possible	Better sensitivity required	Replaced by SPR Biosensor	-
Electrochemical biosensor	Real-time analysis possible	Trouble of reproducibility and measurement errors	Just beginning	In progress at the research level
Fluorescent biosensor	Good sensitivity and simplicity	Fluorescent labeling required and dynamic analysis impossible	Already commercialized	Ongoing as a method for detecting major biomolecules

^*Atomic force microscope.