Fig. 1.

A: Structures of LCAT in the lid-open (left) and -closed (right) states rendered as cartoon models. The cap domain is colored with purple, the α/β hydrolase domain with orange, and the membrane-binding domain with red. The tunnel opening of the active site is marked with a dashed black sphere. The catalytic triad residues: SER181, ASP345, and HIS377 are rendered with sticks and colored according to element types. Cyan atoms are carbon, blue nitrogen, white hydrogen, and red oxygen atoms. B: RSMF profiles for the lid-open and -closed states. RMSD results are shown in the inset. C: Secondary structure profiles for the lid-open and -closed states.