Fig. 1.

The proposed 12R-LOX pathway in the mammalian epidermis and formation of linoleate triols. A: The 12R-LOX/eLOX3 pathway of the mammalian epidermis and proposed involvement of EH forming linoleate triol. The stepwise transformations increase the polarity of the unionized fatty acid moiety (indicated by the decreased lipid/aqueous partition coefficients, cLogP calculated by ChemDraw). B: Previously reported patterns of linoleate triols esterified in Cer-EOS as detected by LC-MS of pig and human epidermis (7). Structures of triol-1 and -3 are the same as illustrated later in Fig. 5A of the Results.