Skip to main content
. 2018 Feb 5;59(4):625–634. doi: 10.1194/jlr.M082040

Fig. 5.

Fig. 5.

KD inhibited growth of PANC-1 but not HeLa cell xenograft tumors in nude mice. A: The KD was associated with significantly lower growth and weight of PANC-1 xenograft tumors in comparison to the same parameters in the STD group (*P < 0.05, left and middle panels). The KD also significantly prolonged the mean survival of mice with PANC-1 xenograft tumors (*P < 0.05, right panel). Kaplan-Meier method and log-rank test were applied to determine mouse survival. B: KD nominally increased tumor growth (left) and weight (middle) in HeLa cell-xenografted nude mice and significantly decreased the mean survival (**P < 0.01). C: Body weight of the xenografted mice. Data are expressed as mean ± SD. *P < 0.05 compared with the control. D: The blood glucose and βHB levels in PANC-1 and HeLa xenografted mice. (E, F) The expressions of BDH1 and OXCT1 mRNA and protein in xenografted tumors. Data are expressed as mean ± SD; n = 3; P values were obtained by a two-tailed Student’s t-test. For protein expression, positive expression was shown as yellow or brown.