Fig. 7.

Δ⁹-THC and Fabp1 gene ablation impact hepatocyte protein levels of membrane proteins and cytosolic proteins involved in uptake and cytosolic binding/chaperoning of bound Δ⁹-THC, AEA, 2-AG, and/or fatty acids such as ARA. All conditions were as in the legend to Fig. 6, except that Western blot analysis was performed to determine levels of FATP2 (A), FATP4 (B), FABP1 (C), HSP70 (D), and SCP-2 (E). The insets show representative Western blots of the respective protein (upper blot) and the gel-loading control protein (37 kDa GAPDH, lower blot). Relative protein was normalized to internal control and WT was set to 1. Values represent the mean ± SEM, n = 4–6. #P < 0.05 versus WT in the same treatment groups; *P < 0.05 versus untreated of the same genotype.