Table 2. Correlations between the density of CD8⁺tTILs^IM and the clinicopathological factors.

	Exploratory Group CD8+tTILsIM			Validation Group CD8+tTILsIM
	Low	High	p-value	Low	High	p-value
Gender
Male	33	39		23	66
Female	36	31	0.398	13	72	0.095
Age (years)
<65	35	30		14	47
≥65	34	40	0.397	22	91	0.695
Tumor depth*
T1-3	41	51		26	91
T4	28	19	0.109	10	47	0.553
Tumor diameter (cm)
<5	33	32		21	80
≥5	36	38	0.866	15	58	1.000
Tumor location
Right side	19	14		11	47
Left side	50	56	0.325	25	91	0.843
Histological type
Well, Moderate	64	63		32	130
Poorly, Mucinous	5	7	0.764	4	8	0.274
Lymphatic involvement
Negative	12	18		9	45
Positive	57	52	0.303	27	93	0.425
Venous involvement
Negative	53	60		25	109
Positive	16	10	0.198	11	29	0.267
Lymph node metastasis
Negative	29	43		19	77
Positive	40	27	0.028	17	61	0.851
CEA (ng/ml)
<5	39	48		22	80
≥5	30	22	0.163	14	56	0.851
CA19-9 (U/ml)
<37	58	65		32	123
≥37	8	5	0.389	3	12	1.000

^*: According to UICC.TNM Classification of Malignant Tumors (seventh edition).

CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9.