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. 2018 Feb 22;9(20):15266–15274. doi: 10.18632/oncotarget.24555

Figure 4. Improvement of the sensitivity of PIK3CA-H1047R detection.

Figure 4

cfDNA fragments harboring PIK3CA (no am) were amplified by ddPCR (am) and then fragments encoding wild-type PIK3CA were cleaved using the CRISPR/Cas9 system (am-Cas9). PIK3CA-H1047R was detected at each step by ddPCR. All data represent mean ± SEM (n = 3). *P < 0.05 (t test).