Table 1.
Baseline characteristics of study subjects
| Maximal‐tolerated‐dose group (n = 333) | Low‐dose group (n = 162) | P‐value | |
|---|---|---|---|
| Age, years | 59.5±11.5 | 58.4±11.2 | 0.297a |
| Male sex, n (%) | 72(21.6) | 42(25.9) | 0.286b |
| Height, cm | 165.3±7.6 | 164.69±11.2 | 0.542c |
| Weight, cm | 65.5±10.7 | 64.9±11.1 | 0.551c |
| Body surface area, m2 | 1.9±0.2 | 1.92±0.2 | 0.589a |
| Hypertension | 122(37.1) | 58(36.9) | 0.976b |
| Diabetes | 76(23.1) | 36(22.9) | 0.967b |
| Dyslipidaemia | 29(8.8) | 9(5.7) | 0.230b |
| Stroke | 20(6.1) | 13(8.3) | 0.367b |
| Smoking | |||
| Never smoked | 140(42.9) | 57(36.5) | 0.210b |
| Current smoker | 154(47.2) | 87(55.8) | |
| Past smoker | 32(9.8) | 12(7.7) | |
| Killip classification | |||
| Class I | 192(59.8) | 90(59.2) | 0.566d |
| Class II | 97(30.2) | 48(31.6) | |
| Class III | 27(8.4) | 14(9.2) | |
| Class IV | 5(1.5) | 0(0.0) | |
| Infarct size (CK‐MB), U/L | 145.40±191.13 | 128.96±196.22 | 0.039c |
| Infarct site, anterior | 249(75.6) | 125(77.6) | 0.632b |
| Infarct‐related artery | |||
| Left main | 0(0.0) | 1(1.1) | 0.517d |
| LAD | 130(69.9) | 67(71.3) | |
| LCX | 14(7.5) | 8(8.5) | |
| RCA | 42(22.6) | 18(19.2) | |
| TIMI flow of infarct‐related artery | |||
| 0 | 103(55.7) | 45(47.8) | 0.671b |
| 1 | 36(19.4) | 21(22.3) | |
| 2 | 17(9.2) | 10(10.6) | |
| 3 | 29(15.7) | 18(19.2) | |
| Thrombolytic therapy | 25(7.5) | 7(4.3) | 0.176b |
| Percutaneous coronary intervention | |||
| Primary | 267(86.4) | 123(83.1) | 0.530b |
| Rescue | 36(11.6) | 20(13.5) | |
| Delayed | 6(1.9) | 5(3.4) | |
| Coronary artery bypass graft | 1(0.3) | 3(1.8) | 0.105d |
| Concomitant drugs | |||
| Aspirin | 330(99.1) | 161(99.4) | 0.421b |
| Thienopyridine | 328(98.5) | 158(97.5) | 0.618b |
| Beta‐blockers | 316(94.9) | 152(93.8) | 0.616b |
| ACE inhibitors | 40(13.4) | 11(8.0) | 0.104b |
| Statins | 181(60.7) | 86(62.8) | 0.685b |
| Aldosterone antagonist | 28(9.4) | 9(6.6) | 0.326b |
| Digoxin | 8(2.7) | 3(2.2) | 1.000d |
| Diuretics | 96(32.2) | 36(26.3) | 0.211b |
| Loop diuretics | 73(24.5) | 27(19.7) | 0.270b |
| Thiazide diuretics | 13(4.4) | 4(2.9) | 0.471b |
ACE, angiotensin‐converting enzyme; LAD, left anterior descending artery; LCX, left circumflex artery; RCA, right coronary artery. Values are absolute and relative frequencies for categorical variables and mean ± standard deviation for continuous variables. Values are n, N/n (%), mean ± SD.
a
Wilcoxon rank sum test.
b
χ2 test.
c
Two‐sample t‐test.
d
Fisher's exact test.