TABLE.
Patient Demographics of All Cohorts and Subcohorts Analyzed
| Cohort/ Subcohort |
DBS Center |
No. (female) |
Age, yr |
Disease Duration, yr |
UPDRS-III Baseline, OFF Medication |
L-dopa Response, % |
Clinical Assessment |
UPRDS-III Improvement, OFF Medication, % |
LEDD Reduction, % |
Postop Imaging |
Related Citations |
|---|---|---|---|---|---|---|---|---|---|---|---|
| B | Berlin | 51 (18) | 60.0 ± 7.9 | 10.4 ± 3.9 | 38.6 ± 12.9 | 53.5 ± 17.2 | ON vs OFF stim at 1–2 years postop | 45.3 ± 23.0 | 52.8 ± 41.6 | MRI, n = 45; CT, n = 6) | — |
| B1 | 16 (9) | 53.6 ± 5.5 | 9.8 ± 3.2 | 41.4 ± 14.5 | 54.5 ± 17.9 | 55.1 ± 15.7 | 74.9 ± 28.0 | Schuepbach 20131 | |||
| B2 | 11 (5) | 66.1 ± 4.8 | 10.8 ± 4.1 | 36.4 ± 12.8 | 48.3 ± 19.3 | 37.2 ± 22.3 | 45.6 ± 36.3 | — | |||
| B3 | 12 (1) | 59.8 ± 7.7 | 10.8 ± 4.8 | 37.2 ± 9.7 | 57.2 ± 15.1 | 54.9 ± 24.0 | 54.6 ± 30.4 | Schmitz-Hubsch 201451 | |||
| B4 | 12 (3) | 63.1 ± 7.5 | 10.5 ± 3.9 | 38.1 ± 13.9 | 53.9 ± 18.7 | 30.1 ± 22.0 | 25.8 ± 57.3 | ||||
| W | Wurzburg | 44 (12) | 60.4 ± 8.2 | 12.6 ± 4.5 | 49.6 ± 13.6 | 61.8 ± 18.4 | Preop vs ON stim postop at 6–12 months | 49.3 ± 24.8 | 61.4 ± 25.1 | CT | — |
Average values ± standard deviation are reported.
CT = computed tomography; DBS = deep brain stimulation; LEDD = L-dopa equivalent dose; MRI = magnetic resonance imaging; Postop = postoperative; Preop = preoperative; stim = stimulation; UPRDS = Unified Parkinson Disease Rating Scale.