Table 2.
Outcome and Characteristics Across Families of Different Relatedness and Counts of Subjects Diagnosed With ASD, AD, and SD
| Outcome | Family types | ||||||
|---|---|---|---|---|---|---|---|
| mPCs | CCs | pPCs | pHSs | mHSs | Unpaired | Total | |
| Number of Families | 55,117 | 104,400 | 54,776 | 5185 | 6658 | 46,733 | 272,869 |
| Number of Children | 168,054 | 316,489 | 166,454 | 11,780 | 14,865 | 98,570 | 776,212 |
| Male, n (%) | 86,272 (51.34) | 163,214 (51.57) | 85,720 (51.50) | 6007 (50.99) | 7753 (52.16) | 50,927 (51.67) | 399,893 (51.52) |
| Female, n (%) | 81,782 (48.66) | 153,275 (48.43) | 80,734 (48.50) | 5773 (49.01) | 7112 (47.84) | 47,643 (48.33) | 376,319 (48.48) |
| Number of Cases | |||||||
| ASD | 2317 | 4397 | 2255 | 275 | 421 | 1566 | 11,231 |
| AD | 962 | 1798 | 889 | 94 | 168 | 643 | 4554 |
| SD | 1355 | 2599 | 1366 | 181 | 253 | 923 | 6677 |
| Outcome Rate (Cases per 1,000 Persons) | |||||||
| ASD | 13.79 | 13.89 | 13.55 | 23.34 | 28.32 | 15.89 | 14.47 |
| AD | 5.72 | 5.68 | 5.34 | 7.98 | 11.30 | 6.52 | 5.87 |
| SD | 8.06 | 8.21 | 8.21 | 15.37 | 17.02 | 9.36 | 8.60 |
AD, autistic disorder; ASD, autism spectrum disorder; CCs, cross cousins; mHSs, maternal half siblings; mPCs, maternal parallel cousins; pHSs, paternal half siblings; pPCs, paternal parallel cousins; SD, Asperger and pervasive development disorders not otherwise specified combined; Unpaired, full siblings not paired to cousins or half-siblings.