TABLE 1.
AGE-STANDARDIZED BASELINE CHARACTERISTICS ACCORDING TO PPI USE
| Nurses’ Health Study (2000) | Health Professionals Follow-Up Study (2004) | |||
|---|---|---|---|---|
| Non-user (n=64,055) | Regular user (n=4,459) | Non-user (n=24,326) | Regular user (n=4663) | |
| Age, years | 65.7 (7.1) | 65.7 (7.1) | 69.9 (8.6) | 69.9 (8.5) |
| Smoking, % | ||||
| Never | 45 | 42 | 53 | 49 |
| Past | 46 | 51 | 44 | 48 |
| Current | 9 | 7 | 3 | 3 |
| Exercise, mean MET-hrs/wk | 17.5 (22.1) | 13.9 (18.2) | 45.4 (47.3) | 40.4 (45.2) |
| BMI, kg2/mg2 | 26.6 (5.3) | 28.3 (5.8) | 25.6 (4.9) | 25.9 (4.9) |
| Regular ASA usage, % | 26 | 24 | 59 | 62 |
| Regular NSAID usage, % | 28 | 29 | 18 | 20 |
| Past/current PMH, % | 46 | 52 | N/A | N/A |
| AHEI score | 50.0 (9.6) | 49.4 (9.4) | 52.4 (10.8) | 51.8 (10.5) |
| Hypertension, % | 47 | 63 | 49 | 60 |
| Hyperlipidemia, % | 59 | 73 | 59 | 68 |
| Coronary Heart Disease, % | 3 | 5 | 9 | 12 |
| Diabetes Mellitus, % | 8 | 11 | 10 | 11 |
| GERD, % | 8 | 37 | 23 | 72 |
| Prior PUD, % | 9 | 28 | 9 | 22 |
| Prior GI bleed, % | 2 | 6 | 4 | 8 |
| Past/current H2RA usage, % | 15 | 66 | 12 | 49 |
Values are means (SD) or percentages and are standardized to the age distribution of the study population.
MET: metabolic-equivalent task, BMI: body mass index, ASA: acetylsalicylic acid, NSAID: non-steroidal anti-inflammatory drug, AHEI: Alternative Healthy Eating Index, GERD: gastroesophageal reflux disease, PUD: peptic ulcer disease, GI: gastrointestinal, H2RA: histamine-2 receptor antagonist
Regular use of either ASA or NSAIDs defined as ≥2 tablets per week. PMH use measured only among post-menopausal females.