Presence of characteristic urate crystals in the joint fluid * Presence of a tophus proven to contain urate crystals by chemical means or polarized light microscopy * Presence of six of the following clinical, laboratory, and radiographic phenomena:
Unilateral attack involving first metatarsophalangeal joint.
Development of maximal inflammation within 1 day.
Attack of mono-articular arthritis.
More than one attack of acute arthritis.
Pain or swelling in first metatarsophalangeal (MTP) joint
Observation of joint redness.
Unilateral attack involving tarsal joint.
Suspected tophus.
Hyperuricemia.
Asymmetric swelling within a joint on x-ray.
Subcortical cysts without erosions on x-ray.
Negative culture of joint fluid for microorganisms during attack of joint inflammation
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Any two of the following:
Presence of urate crystals in synovial fluid or tissues.
Painful joint swelling, abrupt onset, clearing in 1–2 weeks initially.
Serum uric acid >7 mg/dl in males or > 6 mg/dl in females.
Presence of tophi.
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urate crystals in joint fluid or tissue or tophus * Any two of the following:
Response to colchicine – major reduction in inflammation within 48 hours.
Abrupt onset and remission in 1–2 weeks initially.
2 attacks of painful limb joint swelling.
First MTP attack.
Presence of a tophus.
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