Table 2.
Patient characteristics, Major associated co-morbidities and medication use among Olmsted County, Minnesota residents with incident gout in 1989–1992 compared with 2009–2010.
| Characteristic | 1989–1992 (N=158) | 2009–2010 (N=271) | p value |
|---|---|---|---|
| Age at diagnosis, years, mean (SD) | 59.3 (17.9) | 60.0 (17.0) | 0.68 |
| Sex, Male | 116 (73%) | 196 (72%) | 0.81 |
| Race and Ethnicity | |||
| Caucasian | 149 (94%) | 244 (90%) | 0.17 |
| Black or African-American | 1 (1%) | 2 (1%) | |
| Somali | 0 (0%) | 2 (1%) | |
| Asian | 5 (3%) | 12 (4%) | |
| Native Hawaiian/Pacific Islander | 1 (1%) | 0 (0%) | |
| Other | 0 (0%) | 9 (3%) | |
| Unknown | 2 (1%) | 2 (1%) | |
| Smoking | |||
| Never | 64 (42%) | 131 (48%) | 0.068 |
| Current | 17 (11%) | 26 (10%) | |
| Former | 72 (47%) | 106 (39%) | |
| Unknown | 0 (0%) | 8 (3%) | |
| Major Associated Comorbidities: | |||
| Body mass index, kg/m2, median (25th, 75th percentile) | 28.3 (24.9, 32.0) | 30.9 (27.4, 35.8) | <0.001 |
| Obesity (body mass index ≥30 kg/m2) | 56 (37%) | 150 (56%) | <0.001 |
| Hypertension | 86 (54%) | 188 (69%) | 0.002 |
| Heart failure | 10 (6%) | 27 (10%) | 0.20 |
| Diabetes mellitus | 9 (6%) | 68 (25%) | <0.001 |
| Renal disease | 18 (11%) | 77 (28%) | <0.001 |
| Coronary artery disease | 36 (23%) | 53 (20%) | 0.43 |
| Stroke | 7 (4%) | 20 (7%) | 0.24 |
| Hyperlipidemia | 33 (21%) | 164 (61%) | <0.001 |
| Total cholesterol* mg/dL, median (25th, 75th percentile) | 214 (188, 244) | 179 (152, 207) | <0.001 |
| Low-density lipoprotein cholesterol*, mg/dL, median (25th, 75th percentile) | 136 (66, 267) | 96 (74, 126) | <0.001 |
| High density lipoprotein cholesterol*, mg/dL, median (25th, 75th percentile) | 39 (33, 48) | 43 (35, 52) | 0.014 |
| Triglycerides*, mg/dL, median (25th, 75th percentile) | 174 (107, 246) | 142 (103, 212) | 0.075 |
| Serum uric acid level**, mg/dL, mean (SD) | 8.0 (1.8) | 8.2 (2.0) | 0.65 |
| Number tested | 107 | 179 | |
| Medication use: | |||
| Diuretic use | 68 (43%) | 130 (48%) | 0.32 |
| Aspirin | 36 (23%) | 107 (39%) | <0.001 |
| Statin | 7 (4%) | 111 (41%) | <0.001 |
Values in table are n (%) unless otherwise specified.
*
Available lipid values for 1989–1992 and 2009–2010, respectively: Total cholesterol n=126 and n=215; low density and high density lipoprotein cholesterol n=79 and n=215; triglycerides n=116 and n=216.
**
at incidence date to 2 weeks post incidence date; n=107 for 1989–1992 and n=179 for 2009–2010.
Abbreviations: SD: standard deviation