Table 4.
Association between regular aspirin and non-aspirin NSAID use and incident pancreatic cancer stratified by diabetes status.
| Aspirin* | Non-aspirin NSAIDs* | |||||
|---|---|---|---|---|---|---|
| Diabetes Status | Nonregular users | Regular users | Pinteraction✚ | Nonregular users | Regular users | Pinteraction✚ |
| Diabetes | 0.05 | 0.91 | ||||
| No | ||||||
| No. cases | 483 | 427 | 570 | 224 | ||
| Person-years | 2,332,301 | 1,566,450 | 1,964,554 | 810,961 | ||
| Age-adjusted RR (95% CI) | 1 | 1.03 (0.90, 1.17) | 1 | 0.99 (0.84, 1.16) | ||
| Multivariable RR (95% CI)§ | 1 | 1.01 (0.89, 1.16) | 1 | 1.03 (0.88, 1.21) | ||
| Yes | ||||||
| No. cases | 110 | 102 | 143 | 57 | ||
| Person-years | 153,227 | 162,786 | 183,406 | 86,047 | ||
| Age-adjusted RR (95% CI) | 1 | 0.75 (0.57, 1.00) | 1 | 0.97 (0.71, 1.34) | ||
| Multivariable RR (95% CI)§ | 1 | 0.71 (0.54, 0.94) | 1 | 1.02 (0.74, 1.41) | ||
CI, confidence interval; NSAIDs, nonsteroidal anti-inflammatory drugs; RR, relative risk
Current exposure, aspirin and non-aspirin NSAID use obtained from the most recent questionnaire cycle.
Multivariate models conditioning on age (months) and questionnaire cycle and adjusted for sex/cohort, race (White, Black, other, unknown), BMI in kg/m2 (<25.0, 25.0–29.9, 30.0–34.9, ≥35.0, missing), smoking in pack-years (never, <5, 5–19, 20–39, ≥40, missing), alcohol intake in grams/day (0, 0.1–4.9, 5.0–14.9, 15.0–29.9, ≥30.0, missing), multivitamin use (yes/no), physical activity (quintiles by sex), and regular use of aspirin (yes/no) or non-aspirin NSAID (yes/no/missing) depending on the primary exposure.
Tests for interaction performed by entering into the model a cross-product term of regular aspirin or non-aspirin NSAID use (yes/no) and diabetes mellitus (yes/no).