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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Addict Biol. 2017 Oct 2;23(5):1032–1045. doi: 10.1111/adb.12553

Figure 3. HCRTr1 knockdown delays acquisition of cocaine self-administration and reduces motivation for cocaine.

Figure 3

(A) Timeline of surgical procedures and experimental testing. Shown are the mean ± SEM (B) number of days required to reach acquisition criteria, (C) latency to first lever press, and (D) intake rate (i.e., injections/hr) under a fixed-ratio 1 schedule of reinforcement for rats treated with SCRM-shRNA-AAV10 (SCRM) or HCRTr1-shRNA-AAV10 (KD). (E) Shown are the mean ± SEM breakpoints across the 10-day progressive ratio schedule for SCRM and KD animals. * p < 0.05.