Odds ratios for the associations between derived glycan traits and clinical traits in UC (duration of disease: <5 years = 0, >5 years = 1, disease location: E1 (proctitis) + E2 (left-sided UC) = 0, E3 (extensive UC) = 1, and surgery: no = 0, yes = 1) for all IgG subclasses are shown for the ITA cohort (green) and the US cohort (red). Bars indicate positive/negative odds ratios. Derived glycan traits are explained in Supp. Table 3.-4. and their glycoforms in Supp. Table 2. Analysis of the association between derived glycan traits and clinical characteristics in UC were performed using a logistic regression model with age and sex included as additional covariates, statistically significant findings are indicated with an asterisk (*) (Supp. Table 12.).