Odds ratios for the associations between derived glycan traits and clinical characteristics in CD (duration of disease: <5 years = 0, >5 years = 1, disease location: L1 (ileal CD)= 0, L3 (ileocolonic CD) = 1, behavior: B1 (inflammatory CD) = 0, B2 (structuring CD) + B3 (penetrating CD) = 1, and surgery: no = 0, yes = 1) for all IgG subclasses are shown for the ITA cohort (green) and the US cohort (red). Bars indicate positive/negative odds ratios. Derived glycan traits are explained in Supp. Table 3.-4. and their glycoforms in Supp. Table 2. Analysis of the association between derived glycan traits and clinical characteristics in CD were performed using a logistic regression model with age and sex included as additional covariates, statistically significant findings are indicated with an asterisk (*) (Supp. Table 14.).