Table 1.
Hepatitis C Medications
| Generic | Brand | Genotype(s) | Drug class | Considerations |
|---|---|---|---|---|
| Sofosbuvir/velpatasvir | Epclusa | 1–6 | Sofosbuvir: NS5B polymerase inhibitor Velpatasvir: NS5A inhibitor |
Cannot be used in renal disease |
| Elbasvir/grazoprevir | Zepatier | 1, 4 | Elbasvir: NS5A inhibitor Grazoprevir: NS3/4A protease inhibitor |
Can be used with renal disease Not to be used in decompensated (Child B/C) cirrhosis |
| Daclatasvir | Daklinza | 1, 3 | Daclatasvir: NS5A inhibitor Used with sofosbuvir: NS5B polymerase inhibitor |
Efficacy reduced in cirrhosis Different dosage pills available for concomitant use of some drugs, including HIV medications |
| Glecaprevir/pibrentasvir | Mavyret | 1–6 | Glecaprevir: NS3/4A protease inhibitor Pibrentasvir: NS5A inhibitor |
Not recommended in patients with Child B, contraindicated in Child C Can be used in renal patients DAA treatment failures with NS5A or NS3/4A failures |
| Ombitasvir, paritaprevir, ritonavir | Technivie | 4 | Ombitasvir: NS5A inhibitor Paritaprevir: NS3/4A protease inhibitor Ritonavir: CYP3A inhibitor |
Contraindicated in patients with decompensated (Child B/C) cirrhosis With ribavirin |
| Ombitasvir, paritaprevir, ritonavir, dasabuvir | Viekira Pak (XR) | 1 | Ombitasvir: NS5A inhibitor Paritaprevir: NS3/4A protease inhibitor Ritonavir: CYP3A inhibitor Dasabuvir: NS5B polymerase inhibitor |
Contraindicated in patients with decompensated (Child B/C) cirrhosis With ribavirin in 1a patients |
| Ledipasvir/sofosbuvir | Harvoni | 1, 4,5, 6 | Sofosbuvir: NS5B polymerase inhibitor Ledipasvir: NS5A inhibitor |
Cannot be used in renal disease |
| Simeprevir | Olysio | 1 | Simeprevir: NS3/4A protease inhibitor | Used in combination with sofosbuvir Contraindicated in patients with decompensated (Child B/C) cirrhosis |
| Sofosbuvir | Sovaldi | 1–6 | Sofosbuvir: NS5B polymerase inhibitor | Used in combination with other medications |
| Sofosbuvir/velpatasvir/voxilaprevir | Vosevi | 1–6 Prior treatment experience |
Sofosbuvir: NS5B polymerase inhibitor Velpatasvir: NS5A inhibitor Voxilaprevir: NS3/4A protease inhibitor |
Genotypes 1–6 previously treated with NS5A Genotypes 1, 3 previously treated with sofosbuvir without NS5A |