Table 3.

Results of Cox Proportional Hazards Models of Time to Dementia for Older Adult Patients with Hypertension by Any Antihypertensive Medication Usage, With and Without Adjusting for Blood Pressure Control*

Variable	Models without adjusting for ApoE ε4			Models adjusting for ApoE ε4
	Models without adjusting for blood pressure control (n = 1234 and 707)
	HR	95% CI	p value	HR	95% CI	p value
Prescribed any antihypertensive medication	0.57	0.37–0.88	0.01	0.65	0.38–1.12	0.12
Not prescribed antihypertensive medication	Ref			Ref
Age at baseline	1.11	1.08–1.15	<0.001	1.12	1.08–1.16	<0.001
Years of education	0.89	0.84–0.95	<0.001	0.88	0.82–0.95	<0.001
Male	0.96	0.61–1.53	0.87	0.85	0.46–1.55	0.59
Female
Coronary artery disease	1.03	0.66–1.60	0.90	0.85	0.51–1.42	0.53
Chronic renal disease	0.94	0.48–1.83	0.85	1.32	0.63–2.77	0.46
Heart failure	1.10	0.67–1.80	0.72	1.13	0.63–2.03	0.69
Transient ischemic attack	1.14	0.57–2.27	0.71	1.21	0.55–2.70	0.64
Stroke	1.56	0.70–3.51	0.28	1.53	0.62–3.76	0.35
Atrial fibrillation	0.69	0.34–1.39	0.30	0.83	0.39–1.78	0.63
Diabetes - type 1 or 2	0.92	0.62–1.38	0.69	0.85	0.51–1.40	0.52
Chronic obstructive pulmonary disease	0.45	0.18–1.15	0.10	0.54	0.21–1.44	0.22
Cancer	0.61	0.41–0.90	0.01	0.55	0.34–0.87	0.011
ApoE ε4 carriers	N/A	N/A	N/A	2.07	1.30–3.29	0.002
	Models adjusting for blood pressure control (n = 838 and 560)
Prescribed any antihypertensive medication	0.65	0.32–1.30	0.22	0.96	0.38–2.44	0.93
Not prescribed antihypertensive medication	Ref			Ref
Age at baseline	1.13	1.08–1.17	<0.001	1.15	1.10–1.20	<0.001
Years of education	0.88	0.81–0.95	0.002	0.85	0.77–0.95	0.003
Male	0.96	0.54–1.73	0.90	1.06	0.49–2.29	0.87
Female
Blood pressure suboptimally treated	1.78	1.11–2.86	0.02	2.19	1.22–3.94	0.009
Coronary artery disease	1.15	0.66–2.02	0.62	0.99	0.51–1.92	0.98
Chronic renal disease	1.01	0.45–2.26	0.98	1.37	0.55–3.40	0.50
Heart failure	1.23	0.65–2.30	0.52	1.09	0.52–2.28	0.82
Transient ischemic attack	1.34	0.63–2.89	0.45	1.44	0.58–3.55	0.43
Stroke	1.15	0.38–3.48	0.81	0.86	0.23–3.16	0.82
Atrial fibrillation	0.60	0.26–1.40	0.24	0.74	0.29–1.90	0.53
Diabetes - type 1 or 2	0.70	0.42–1.18	0.18	0.72	0.37–1.38	0.32
Chronic obstructive pulmonary disease	0.40	0.12–1.33	0.14	0.51	0.15–1.77	0.29
Cancer	0.76	0.47–1.24	0.27	0.72	0.40–1.28	0.26
ApoE ε4 carriers	N/A	N/A	N/A	2.11	1.15–3.88	0.017

*HR = hazard ratio; 95% CI = 95% confidence interval