Fig. 1.

Animal experimental model and colon length measurement. A. Schematic diagram of DSS-induced colitis in mouse. The DSS and DSS+SAHA groups received 1.5% DSS in drinking water for 5 days, followed by a switch to normal drinking water. The SAHA and DSS+SAHA groups were treated with daily intraperitoneal injection of SAHA at a dose of 25 mg/kg. B. Macrophotography of the mouse colon on day 12. C. Colon length on days 5 and 12 in all experimental groups. Asterisks indicate statistically significant differences (*p < 0.05). Data represent the mean ± SD of 6–9 mice.