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. 2018 Apr 3;9:1306. doi: 10.1038/s41467-018-03755-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — IR cleavage in tumors. a Pearson’s correlation of the changes in IRA mRNA levels in hepatocellular carcinoma vs. normal tissue with those of BACE1 (values are expressed in Log₂). Pearson’s correlation coefficient (r) and p-value are reported. b IR mRNA levels were measured by RT-PCR in tumors from native Huh7 cells and from Huh7 cells overexpressing IRA (Huh7 IRA). c IRsol was measured in the plasma of mice-bearing tumors from native Huh7 cells and from Huh7 cells overexpressing IRA (Huh7 IRA). Data are means ± s.d. **p < 0.01; ***p < 0.001. d Correlation of IRA (circles) and IRB (squares) mRNA levels in tumors from native Huh7 cells with IRsol plasma levels (IRsol values are expressed as fold over the mean). Pearson’s correlation coefficient (r) and p-value are reported (NS, no significant correlation)