Table 5.
Multivariate prognostic analyses in pT4 colon and rectosigmoid cancer (N = 130)
| Prognostic factors | Hazard ratio | 95% CI | p value |
|---|---|---|---|
| OS | |||
| Age (≥ 74 against < 74) (years) | 1.75 | 0.80–3.72 | 0.159 |
| Gender (male against female) | 3.09 | 1.58–6.48 | < 0.001 |
| CEA (≥ 4.8 against < 4.8) (ng/ml) | 1.64 | 0.87–3.17 | 0.128 |
| Tumor location (right-sided against left sided) | 2.11 | 1.01–4.46 | 0.047 |
| Lymph node ratioa (≥ 0.06 against < 0.06) | 2.35 | 1.13–5.17 | 0.021 |
| Lymphatic invasion (ly3 against ly0/1/2) | 1.88 | 0.82–4.03 | 0.132 |
| Vascular invasion (v3 against v0/1/2) | 1.91 | 0.96–3.70 | 0.066 |
| Tumor diameter (< 38 against ≥ 38) (mm) | 2.57 | 1.30–5.09 | 0.007 |
| RFS | |||
| Gender (male against female) | 2.02 | 1.09–3.90 | 0.026 |
| CEA (≥ 4.8 against < 4.8) (ng/ml) | 1.52 | 0.83–2.84 | 0.176 |
| pN (pN0/1 against pN2) | 1.32 | 0.66–2.71 | 0.429 |
| Lymph node ratioa (≥ 0.06 against < 0.06) | 4.76 | 2.08–11.64 | < 0.001 |
| Tumor differentiation (well/moderately against poorly) | 1.20 | 0.40–4.05 | 0.754 |
| Lymphatic invasion (ly3 against ly0/1/2) | 2.18 | 0.86–5.00 | 0.096 |
| Vascular invasion (v3 against v0/1/2) | 1.49 | 0.75–2.83 | 0.248 |
| Adjuvant chemotherapy (absence against presence) | 1.05 | 0.52–2.06 | 0.880 |
CI confidence interval, RFS recurrence-free survival, OS overall survival
aThe ratio of metastatic lymph nodes to total number of harvested lymph nodes