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. 2018 Mar 27;10:85. doi: 10.3389/fnagi.2018.00085

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Copyright © 2018 Li, Ma, Wang, Chen, Hu, Wang, Fu, Shi, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methyl salicylate lactoside (MSL) improved learning and memory in amyloid precursor protein (APP)/presenilin 1 (PS1) mice. (A) Latency to reach the escape platform during five training days in the Morris water maze (MWM) test showed a significant effect on escape latency (F_(4,144) = 117.763, p < 0.001) between groups. (B) During the training period, no significant differences were observed in swimming speed of mice among groups. (C) In the probe test, MSL-treated mice showed a significant increase in the time spent in the target quadrant when compared to the APP/PS1 control mice. (D) In the probe test, MSL-treated mice showed an increase in the number of platform crossings when compared to APP/PS1 control mice. Data are presented as the mean ± SEM, n = 12 mice per group. ***p < 0.001 vs. wild-type (WT) control mice; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. APP/PS1 control mice.