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. 2018 Mar 27;10:85. doi: 10.3389/fnagi.2018.00085

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Copyright © 2018 Li, Ma, Wang, Chen, Hu, Wang, Fu, Shi, Zhang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSL protected ultrastructural neuronal damage and degeneration. (A) Ultrastructural analysis indicated that MSL treatment prevent rupture of the neuronal membrane and edema of neurons in the hippocampus or cortex. (B) Fluoro-Jade B (FJB) staining assay was used to evaluate the effects of MSL treatment on cortical neuronal degeneration. MSL treatment significantly prevented the generation of FJB-positive cells. (C) Mean number of FJB-positive cells/mm² of the cerebral cortex. Data are presented as the mean ± SEM, n = 6 mice per group. ***p < 0.001 vs. WT control mice; ^##p < 0.01, ^###p < 0.001 vs. APP/PS1 control mice.