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. 2018 Mar 27;9:210. doi: 10.3389/fphar.2018.00210

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Copyright © 2018 Zhou, Meng, Yang, Hu, Hong, Lv, Chen, Heng, Jiang, Zhu, Cheng, Zhang, Cao, Wang, Shen, Yan and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CEP inhibited F-actin ring formation and bone resorption in vitro. (A) BMMs were cultured with osteoclastogenic medium for 4 days and subsequently seeded on bone slices in the presence of indicated dilutions of CEP for another 48 h. Cells were fixed and stained to detect F-actin rings. Scale bar = 50 μm. (B) The area of the F-actin rings was quantified. (C) Cells were removed from bone slices and bone resorption pits were observed using SEM. Scale bar = 200 μm. (D) The area of bone resorption pits was measured. Values are expressed as mean ± SD; ^*P < 0.05, ^**P < 0.01 vs. the control group.