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. 2018 Mar 27;11:97. doi: 10.3389/fnmol.2018.00097

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Copyright © 2018 Zhao, Zhang, Tang, Meng, Zou, Wu, Hu, Liu, Feng and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of HC-067047 administration on the expression of adherens/tight junction proteins and activation of the PKCα/RhoA/MLC2 pathway after ICH. (A) Representative bands and quantitative analysis of the expression levels of VE-Cadherin, Occludin, and Claudin-5 24 h following the operation in the sham, vehicle, and HC-067047 treatment groups (150 pmol per rat) are shown. (B) Representative bands and quantitative analysis of the activation of the PKCα/RhoA/MLC2 pathway 24 h following the operation in the sham, vehicle, and HC-067047 treatment groups (150 pmol per rat) are shown, n = 5 rats per group. Data are presented as the means ± standard errors of the means. ^∗∗p < 0.01 compared with the sham group; ^#p < 0.05 compared with the vehicle group.