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. 2018 Mar 27;11:97. doi: 10.3389/fnmol.2018.00097

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Copyright © 2018 Zhao, Zhang, Tang, Meng, Zou, Wu, Hu, Liu, Feng and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of TRPV4 siRNA on neurological deficits and BBB integrity after ICH. (A) Representative bands and quantitative analysis of the inhibitory effect of the TRPV4 siRNA are shown. Relative densities of each protein were normalized to the sham group, n = 5 rats per group. (B) A modified Garcia test and (C) corner Turn test were performed on the sham, vehicle, scrambled siRNA and TRPV4 siRNA groups 24 h after the operation. (D) The Evans blue extravasation evaluation was performed on the sham, vehicle, scrambled siRNA, and TRPV4 siRNA groups 24 h after the operation, n = 6 rats per group. Data are presented as the means ± standard errors of the means. ^∗∗p < 0.01 and ^∗p < 0.05 compared with the sham group; ^#p < 0.05 compared with the vehicle group; ^@p < 0.05 compared with the scrambled siRNA group.