Table 3.
Most common combinations of antimicrobial resistance phenotypes and genotypes in non-typhoidal Salmonella enterica for all serovars, S. Typhimurium and S. Enteritidis.
| Serovar | Antimicrobial classes | Number of isolates (%) | Most common phenotypic combination (number of isolates) | Most common genotypic combination (number of isolates) |
|---|---|---|---|---|
| Total (n = 3491) | 0 | 2190 (62.73) | – | – |
| 1/2 | 453 (12.98) | <CIP (196) | gyrA[87:D-Y] (52) | |
| 3/4 | 514 (14.72) | AMP/STR/SUL/TET (231) | sul2;strA-strB;tet(A);blaTEM-1 (219) | |
| 5/6/7 | 315 (9.02) | AMP/CHL/STR/SUL/TET (37) | sul1;tet(G);aadA17;aadA2;floR;blaPSE-1/blaCARB-2(30) | |
| 8/9 | 19 (0.54) | AMP/CAZ/CHL/< CIP/CPR/CTX/ETP/FOX/GEN/STR/SUL/TET/ TMP/TOB (1) | qnrS1;sul1;sul2;sul3;strA-strB;tet(M);tet(A);dfrA12;aac(3)-Iva;aadA2;aadA12;aph(4)-Ia;cml1;floR;blaCMY -2;blaTEM-1 (1) | |
| S. Typhimurium (n = 827) | 0 | 259 (31.32) | – | – |
| 1/2 | 101 (12.21) | TET (40) | tet(A) (38) | |
| 3/4 | 317 (38.33) | AMP/STR/SUL/TET (230) | sul2;strA-strB;tet(A);blaTEM-1 (220) | |
| 5/6/7 | 138 (16.69) | AMP/CHL/STR/SUL/TET (33) | sul1;tet(G);aadA17;aadA2;floR;blaPSE-1/blaCARB-2(28) | |
| 8/9 | 12 (1.45) | AMP/CAZ/CHL/< CIP/CPR/CTX/ETP/FOX/GEN/STR/SUL/TET/ TMP/TOB (1) | qnrS1;sul1;sul2;sul3;strA-strB;tet(M);tet(A);dfrA12;aac(3)-Iva;aadA2;aadA12;aph(4)-Ia;cml1;floR;blaCMY -2;blaTEM-1 (1) | |
| S. Enteritidis (n = 294) | 0 | 164 (55.78) | – | – |
| 1/2 | 117 (39.80) | <CIP (87) | gyrA[87:D-Y] (24) | |
| ≥3 | 13(4.42) | AMP/ < CIP/STR/SUL/TET (4) | gyrA[87:D-N];sul2;strA-strB;tet(A);blaTEM-1 (3) | |
| S. Kentucky (n = 109) | 0 | 27 (24.77) | – | - |
| 1/2 | 12 (11.01) | AMP/> CIP (5) | gyrA[83:S-F;87:D-Y];parC[57:T-S;80:S-I];blaTEM-1 (4) | |
| 3/4 | 19 (17.43) | AMP/> CIP/SUL/TET (11) | gyrA[83:S-F;87:D-Y];parC[57:T-S;80:S-I];sul1;tet(A);aadA7;blaTEM-1 (3) | |
| 5/6/7 | 51 (46.79) | AMP/> CIP/GEN /STR/SUL/TET (24) | gyrA[83:S-F;87:D-Y];parC[57:T-S;80:S-I];sul1;tet(A);aac(3)-Id;aadA7;blaTEM-1 (20) |
AMP, ampicillin; FOX, cefoxitin; CTX, cefotaxime; CAZ, ceftazidime; CPR, cefpirome; ETP, ertapenem; CHL, chloramphenicol; GEN, gentamicin; STR, streptomycin; TOB, tobramycin; SUL, sulphonamides; TET, tetracycline; TMP, trimethoprim; <CIP, ciprofloxacin MIC 0.06–0.25 mg/L; >CIP, ciprofloxacin MIC > 0.5 mg/L. Values in the column antimicrobial class denote the numbers of antimicrobial classes the isolates are resistant to.