Figure 1.

Schematic representation of SH2 domain-containing tyrosine phosphatase-2 (Shp2) structure (PDB:2SHP). (A) Two-dimensional structure of tyrosine phosphatase Shp2 comprises of N-terminal Src homology 2 (SH2) domain (green), C-SH2 (red) and protein tyrosine phosphatase (PTP) domain (yellow). (B) Ribbon diagram of the crystal structure of full-length Shp2 showing beta sheets and alpha helices. N SH2 domain is shown in green, C SH2 domain in red, PTP domain in yellow and substrate binding region in pink.