Table 3.
CGI-GI, CGI-I, Children’s Yale-Brown Obsessive-Compulsive Scale for Children (CY-BOCS), Premonitory Urge for Tic Scale (PUTS) outcome (values are expressed as absolute scores).
| Time | Behavioral therapy (BT) (n = 25) Mean (SD) | Pharmacotherapy (PT) (n = 50) Mean (SD) | Psychoeducation (PE) (n = 24) Mean (SD) | Treatment F (df1, df2) p | Treatment × time F (df1, df2)p# | |
|---|---|---|---|---|---|---|
| CGI-GI | 0 1 2 |
3.92 (0.99) 3.24 (0.72)* 3.20 (0.87)* |
4.47 (0.77) 3.57 (0.75) * 3.51 (0.54)* |
4.04 (0.86) 4.08 (0.72) 4.00 (0.66) |
F(2.99) = 5.88 p = 0.0039 |
F(4.198) = 9.93 p < 0.0001 |
| CGI-Ia | 0 1 2 |
– 2.24 (0.88)* 4.00 (1.32) |
– 1.94 (0.89)* 3.74 (1.09) |
– 4.00 (0.42) 3.83 (0.48) |
F(2.99) = 30.34 p < 0.0001 |
F(2.99) = 15.64 p < 0.0001 |
| CY-BOCS | 0 1 2 |
8.08 (8.5) 6.60 (7.14) 5.84 (6.69) |
14.36 (12.59) 10.17 (9.44)* 10.23 (9.45)* |
8.29 (9.14) 8.92 (10.20) 8.38 (9.77) |
F(2.99) = 2.49 p = 0.0884 |
F(4.198) = 4.53 p = 0.0030 |
| PUTS | 0 1 2 |
14.68 (7.90) 13.00 (8.46) 12.04 (8.41)* |
10.89 (6.68) 9.15 (5.21)* 9.75 (6.56) |
10.63 (7.57) 10.38 (6.89) 10.13 (6.90) |
F(2.99) = 2.25 p = 0.1103 |
F(4.198) = 1.42 p = 0.2331 |
*p < 0.05. For all variables, but CGI-I, the comparisons are performed between time 1 or time 2 vs time 0, within each treatment group.
aAsterisk refers to the significance value (with Bonferroni’s correction) of the one sample t-test performed within the particular treatment group and time point, assuming the value of 4 as hypothetical mean indicative of no change (see Section “Materials and Methods”). Values of CGI-I significantly lower (or higher) than 4 indicate an improvement (or worsening) of the clinical global index over time.
#Greenhouse-Geisser correction for the sphericity assumption.