Table 2.

Recommended serologic first line diagnostics for autoimmune liver diseases.

Test assay	Antibodies detected
SKL IFT	ANA Anti-SMA Anti-LKM AMA
HEp-2 IFT	ANA patterns indicative of antibodies to mitochondria (AMA), gp210, sp100, and centromere
ELISA or WB	Anti-SLA/LP

AMA, antimitochondrial antibodies; ANA, antinuclear antibodies; ELISA, enzyme-linked immunosorbent assay; GP, glycoprotein; HEp-2 IFT, indirect immunofluorescence testing on HEp-2 cells; LKM, liver–kidney microsome; SMA, smooth muscle antibodies; SKL IFT, indirect immunofluorescence testing on rodent stomach, kidney, and liver tissue; SLA/LP, soluble liver antigen/liver–pancreas antigen; WB, western blot/immunoblot.