Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Mar 27;9:287. doi: 10.3389/fphar.2018.00287

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Rojo de la Vega, Zhang and Wondrak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Topical bixin application activates NRF2 in SKH1 mouse skin. SKH1 Nrf2^+/+ mice were treated with PEG400 vehicle control (-) on half of their dorsal skin and 1% bixin (+) on the other half. Skin tissues were collected 1 day later. (A) Protein expression of NRF2 and its downstream genes in skin tissue lysates as assessed by immunoblot analyses in four individual mice. Protein expression was quantified, normalized, and represented as fold change compared to controls. (B) Histological analyses by H&E and immunohistochemical staining for NRF2 and its target gene GCLM. Images representative of specific treatment groups are shown. Scale bar: 10 μm. ^∗p < 0.05 compared to Ctrl.