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. 2018 Mar 27;9:223. doi: 10.3389/fphar.2018.00223

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Copyright © 2018 Qian, Sun, Wang, Lu, Wu, Dang, Tang, Ji, Liu, Zhao, Wang, Chai, Pan, Yi, Zhang and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of 5 μM DHA on total K⁺ currents in CASMCs. (A) Representative current traces showing outward K⁺ currents recorded from freshly isolated rat CASMCs at baseline, after exposure to 5 μM DHA, and after DHA washout. (B) Plot showing the time course of the experiment in A. (C) I–V relationship of total K⁺ currents at baseline, with application of 5 μM DHA, and after DHA washout. (D) Activation of total outward K⁺ currents in rat CASMCs by 5 μM DHA in the presence of various K⁺ channel blockers. Representative current traces showing the activation of total K⁺ currents in freshly isolated rat CASMCs by 5 μM DHA in the presence of various K⁺ channel blockers. (E) Group data in bar graphs, n = 5 cells, ^∗P < 0.05 inhibitors alone vs. inhibitors + DHA.