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. 2018 Mar 27;9:223. doi: 10.3389/fphar.2018.00223

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Copyright © 2018 Qian, Sun, Wang, Lu, Wu, Dang, Tang, Ji, Liu, Zhao, Wang, Chai, Pan, Yi, Zhang and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of different concentrations of DHA on BK currents and the role of CYP in mediating DHA activation on BK currents in rat CASMCs. (A) Representative current traces showing BK currents at baseline and after exposure to 3 and 10 μM of DHA. (B) Concentration–response relationships showing the effects of DHA on BK channel activation, n = 6 cells. (C) Representative current traces showing BK currents at baseline and after exposure to 3 and 10 μM of DHA in rat CASMCs after incubation with 10 μM SKF525A for 60 min. (D) Concentration–response relationships showing the effects of DHA on BK channel activation with SKF525A pre-incubation, n = 6 cells.