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. 2018 Mar 27;9:223. doi: 10.3389/fphar.2018.00223

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Copyright © 2018 Qian, Sun, Wang, Lu, Wu, Dang, Tang, Ji, Liu, Zhao, Wang, Chai, Pan, Yi, Zhang and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of PLC–IP₃ signal pathway reduces DHA-induced BK activation. (A) Representative current traces showing BK currents at baseline and after exposure to 1 and 5 μM of DHA of rat CASMCs in cells without treatment (control) (a) and those after incubation with U-73122 (b) or 2-APB (c). (B) Group data in bar graphs showing increased current densities after exposure to 1 μM DHA in rat CASMCs with or without pre-incubation with U-73122 or 2-APB in bar graphs, n = 5 cells, ^∗P < 0.05 c vs. control group. (C) Group data of increased current densities after exposure to 5 μM DHA of rat CASMCs with or without pre-incubation, n = 5 cells, ^∗P < 0.05 vs. control.