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. 2018 Mar 27;9:223. doi: 10.3389/fphar.2018.00223

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Copyright © 2018 Qian, Sun, Wang, Lu, Wu, Dang, Tang, Ji, Liu, Zhao, Wang, Chai, Pan, Yi, Zhang and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A proposed model for BK channel activation mechanisms by different concentrations of DHA. Low concentrations of DHA-induced BK channel activation are dependent on CYP epoxygenase activity. High concentrations of DHA activate BK channels directly. In addition, DHA can also induce a dose-dependent increase in [Ca²⁺]_i via the PLC–IP₃–Ca²⁺ signal pathway, and the ensuing increased [Ca²⁺]_i can activate BK channels in rat CASMC.