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| Female sex |
| Age (< 18 years old, > 75 years old) |
| Uncontrolled hypertension or diabetes mellitus |
| Renal failure |
| Previous history of cardiotoxicity |
| Pre-existing heart disease: LV hypertrophy, coronary artery disease |
| Cardiomyopathy: reduced LV ejection fraction |
| Concomitant or previous radiation therapy involving heart |
| Concomitant chemotherapy: anthracyclines/trastuzumab |
LV: left ventricular
