Table 8. Summary for management of cardiovascular toxicity.

Toxicity	Managemen
Heart failure	Avoid risk factors
	Diuretics, BB, MRA, ACEIs or ARBs
	CRT or ICD
Ischemic heart disease	Nitrate or nitroglycerine
	Antiplatelet agent, anticoagulation
	BB, CCB, ACEIs or ARBs
	Lipid-lowering agents
	Coronary revascularization (intervention or surgery)
Hypertension	Diuretics, DHP-CCB, BB, ACEIs or ARBs
Arrhythmia
QT prolongation	Avoid risk factors, ICD in cases of VT or VF
Atrial fibrillation	Rhythm control: cardioversion
	Rate control: BB, digoxin, non-DHP-CCB
Acute pericarditis	Aspirin, NSAID, colchicine
Pericardial effusion	Pericardiocentesis, pericardiotomy
Pulmonary arterial hypertension	Ambrisentan, iloprost
Venous thromboembolism	Anticoagulation

BB: beta blocker, MRA: mineralocorticoid receptor antagonist, ACEIs: angiotensin converting enzyme inhibitors, ARBs: angiotensin receptor blockers, CRT: cardiac resynchronization therapy, ICD: implantable cardioverter defibrillator, CCB: calcium channel blocker, DHP: dihydropyridine, VT: ventricular tachycardia, VF: ventricular fibrillation, NSAID: nonsteroidal anti-inflammatory drug