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. 2018 Mar 27;9:269. doi: 10.3389/fphar.2018.00269

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Copyright © 2018 Mu, Xu, Ma, Li, Ji, Zhang, Amat and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HF maintained normal subchondral bone microarchitecture after ACLT. (A) 3D micro-CT image of tibial subchondral bone medial compartment in sagittal view at 30 and 60 d after sham surgery or ACLT. Scale bar, 500 μm. (B–D) Quantitative analysis of micro-CT parameters of tibial subchondral bone: bone volume fraction (BV/TV) (B), thickness of subchondral bone plate (SBP.Th.) (C) and trabecular pattern factor (Tb.Pf) (D). ^*p < 0.05 as denoted by bar, ^**p < 0.01 as denoted by bar.