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Regulation of HOXD gene expression by lncRNA HOTAIR. Transcribed from the HOXC locus, HOTAIR binds to SUZ12 and EZH2, part of the PRC2 complex. HOTAIR recruits the PRC2 complex and silences the HOXD locus through H3K27me3. (Abbreviations: HOXD, Homeobox D; lncRNA, long non coding RNA; HOTAIR, HOX transcript antisense RNA; SUZ12, SUZ12 Polycomb Repressive Complex 2 Subunit; EZH2, Enhancer of zeste homolog 2; PRC2, polycomb repressive complex 2).
