Table 1.

Modulation of TAAR1 activity on abuse-related behaviors of drugs.

TAAR1 modulation		Treatment	Species	Behavior	Effect	References
Full agonists	RO5166017	Cocaine	Mice	Cocaine-induced hyperlocomotion	↓	Revel et al., 2011, 2013b
			Rats	Expression of CPP	↓	Liu et al., 2016
				Cue- and priming-induced reinstatement of cocaine-seeking	↓	Liu et al., 2017
		DAT−/−	Mice	Spontaneous hyperlocomotion	↓	Revel et al., 2013b
	RO5256390	Cocaine	Mice	Cocaine-induced hyperlocomotion	↓	Revel et al., 2013b
			Rats	Cocaine-seeking after abstinence for 2 weeks	↓	Pei et al., 2014
				Cocaine self-administration	↓	Pei et al., 2015
				Cocaine-induced lowering of ICSS reward thresholds	↓	Pei et al., 2015
		Palatable food	Rats	Eating for a highly palatable sugary diet	↓	Ferragud et al., 2017
Partial agonists	RO5263397	Cocaine	Mice	Cocaine-induced hyperlocomotion	↓	Revel et al., 2013b
			Rats	Cocaine-induced hyperlocomotion	↔	Thorn et al., 2014a,b
				Expression of cocaine-induced sensitization	↓
				Expression of cocaine-CPP	↓	Thorn et al., 2014b
				Development of cocaine-CPP	↔
				Cue- and priming-induced reinstatement of cocaine-seeking	↓
				Cocaine-induced lowering of ICSS reward thresholds	↓	Pei et al., 2015
		METH	Rats	Expression of METH-induced sensitization	↓	Jing et al., 2014
				Cue- and priming-induced reinstatement of METH-seeking	↓
				METH self-administration	↓
				Effects of METH in 5-CSRTT	↓	Xue et al., 2018
				Effects of METH in delay discounting	↔
		Sucrose	Rats	Cue-induced reinstatement of sucrose-seeking	↔	Jing et al., 2014
	RO5073012	AMPH	Mice	AMPH-induced hyperlocomotion	↔	Revel et al., 2012
	RO5203648	Cocaine	Mice	Cocaine-induced hyperlocomotion	↓	Revel et al., 2012a; Pei et al., 2015
			Rats	Cocaine-induced hyperlocomotion	↓
				Self-administration	↓	Pei et al., 2014
				Cocaine-seeking after abstinence for 2 weeks	↓	Cotter et al., 2015
				Priming-induced reinstatement of cocaine-seeking	↓
		METH	Rats	Development of sensitization	↓	Cotter et al., 2015
				Cross-sensitized with METH	↑
				Early phase of METH-induced hyperlocomotion	↓
				Late phase of METH-induced hyperlocomotion	↑
				Self-administration	↓
		DAT−/−	Mice	Spontaneous hyperlocomotion	↓	Revel et al., 2012a
		Sucrose	Rats	Sucrose self-administration	↓	Cotter et al., 2015
TAAR1 knockout		AMPH	Mice	AMPH-induced hyperlocomotion	↑	Lindemann et al., 2008; Achat-Mendes et al., 2012
				Context-dependent sensitization	↑	Sukhanov et al., 2016
				Acquisition of CPP	↔
				Reinstatement of CPP	↑
		METH	Mice	METH-induced hyperlocomotion	↑	Achat-Mendes et al., 2012
				CPP	↑
				METH-induced CTA	↓	Harkness et al., 2015
		Ethanol	Mice	Preference for ethanol in two-bottle choice	↑	Lynch et al., 2013
				Locomotion after ethanol administration	↓
		Morphine	Mice	CPP	↔	Achat-Mendes et al., 2012
		Apomorphine	Mice	Climbing behavior and certain types of stereotypic behavior	↓	Sukhanov et al., 2014
				Apomophine-induced hypolocomotion	↔
		Sucrose	Mice	Preference for sucrose in two-bottle choice	↔	Lynch et al., 2013
TAAR1 overexpression		AMPH	Mice	Hyperactivity	↓	Revel et al., 2012

TAAR1, trace amine-associated receptor 1; CPP, conditioned place preference; CTA, conditioned taste aversion; 5-CSRTT, 5-choice serial reaction time task; AMPH, amphetamine; METH, methamphetamine; DAT, dopamine transporter. ↑, upregulation; ↓ downregulation; ↔ no change.