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The OZR exhibits impaired HVR. (A–C) Effect of hypoxia on VT, fR, and VE in the three groups of rats. (D) The stimulatory effect of hypoxia on VE in three groups of CBD rats. (E) Changes in VE during exposure to 10% O2 between CBI and CBD rats. n = 20 for each group, **P < 0.01 as drawn by two-way ANOVA with Bonferroni post-hoc test. VT, tidal volume; fR, respiratory frequency; VE, minute ventilation; CBI, carotid body innervation; CBD, carotid body denervation.
