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Effect of hypodermic injection of Leptin on breathing parameters. (A–C) Injection of leptin raised VT, fR, and VE measured on 7th day in the LZR with CBI. (D) The stimulatory effect of hypoxia was reduced in two groups of rats with CBD. (E) Changes in VE during exposure to 10% O2 in CBI and CBD groups. n = 8 for each group, *P < 0.05, **P < 0.01 by two-way ANOVA with Bonferroni post-hoc test, Leptin vs. Saline group.
